What do you do when you are hit with litigation or a government investigation where you have hundreds of gigabytes, potentially meaning hundreds of thousands of pages of documents, and a short timeline for production? There are numerous technology-assisted ways to deal with large amounts of data, some of which include early cases assessment (ECA) tools, simple culling, and advanced analytics. Even with all of the technology available, large cases will likely require some form of manual review, but there are limited resources available that explain how to approach such a task. As such, what follows here is a step by step guide for how to manage human review, including both managing the human aspect of review and some basic technical considerations to take into account along the way. This should serve as a starting point for someone new to managing the process or who needs ideas for improving their large scale document review.